Twenty-two to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7–14 years of age showed attenuation of age-related methylation drift compared to ad libitum-fed controls such that their blood methylation age appeared 7 years younger than their chronologic age. Here, we report that epigenetic drift is conserved across species and the rate of drift correlates with lifespan when comparing mice, rhesus monkeys, and humans. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. James was left massively disfigured from the incident.ĭespite everything, the couple continued to visit Moe until he mysteriously disappeared from the sanctuary.In mammals, caloric restriction consistently results in extended lifespan. After five minutes, LaDonna's screams caught the attention of the sanctuary owner's son. James jumped in to save his wife, and became the main victim of the attacking primates. Jealous of the Davises' attention to Moe, one went directly after LaDonna, biting her thumb off after an attempted tackle.
Tragically, two chimpanzees escaped from their cages. One fateful day, the Davises were visiting Moe at the sanctuary for his 39th birthday. Many legal battles ensued, and Moe was eventually granted the right to stay at a sanctuary for apes, where the Davises could visit him. After a raid by police and animal control, Moe was eventually taken away by the state. When Moe was in his 30s, he began to display aggressive behaviors. The trio gained local fame, and Moe even made some TV appearances. They ate, slept, and watched TV together. Over the years, the human couple and their chimpanzee lived together in West Covina, CA, a suburb about 20 miles east of Los Angeles. Not long afterward, he and LaDonna finally married. Eventually, he came home, but he wasn't alone - he brought Moe, a newborn chimpanzee he had rescued from the wild, back home with him. James left LaDonna at the alter and then skipped town shortly after on a boat headed for Africa. They had planned to get married fresh out of high school - that is, until St. James and LaDonna Davis were high school sweethearts.
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